| 王黎明,昌盛,金瑛.金鸡纳生物碱衍生物催化β-萘酚和N-Ts芳香酰亚胺的不对称aza-Friedel-Crafts反应[J].分子催化,2013,(6):502-506 |
| 金鸡纳生物碱衍生物催化β-萘酚和N-Ts芳香酰亚胺的不对称aza-Friedel-Crafts反应 |
| Cinchona alkaloid Derivatives Catalyzed Asymmetric Aza-Friedel-Crafts Reaction of 2-Naphthol with Tosylimines |
| 投稿时间：2013-10-26 修订日期：2013-11-28 |
| DOI： |
| 中文关键词: 金鸡纳生物碱衍生物 不对称催化 aza-Friede-Crafts反应 β-萘酚 Betti碱 |
| 英文关键词:Cinchona alkaloid derivative asymmetric catalysis aza-Friede-Crafts reaction β-naphthol Betti base |
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| 中文摘要: |
| 将金鸡纳生物碱衍生物用于催化β-萘酚和芳香酰亚胺的不对称aza-Friedel-Crafts反应制备Betti碱衍生物。考察溶剂、温度及催化剂用量对反应催化性能的影响。结果表明，最佳催化条件为10 mmol%催化剂1c，甲苯为溶剂，0oC反应。得到了70-86％的化学产率和最高达80％ee的对映选择性. |
| 英文摘要: |
| Cinchona alkaloid derivatives as organocatalysts were applied in asymmetric aza-Friedel-Crafts reaction of 2-naphthol with tosylimines to synthesize Betti base derivatives. The effect of solvent, temperature and catalyst loading ammount were investigated. The optimized conditions were confirmed to include toluene as the solvent with a 10 mol% loading of catalyst 1c at 0 °C. The products were obtained in 70-86％yield, with up to 80％ee. |
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