魏钊,杨化萌,张金龙,蒋高喜.酸催化的二芳基甲醇脱水环化氧化芳构化直接构筑4-芳基喹啉[J].分子催化,2019,33(4):371-381 |
酸催化的二芳基甲醇脱水环化氧化芳构化直接构筑4-芳基喹啉 |
Direct Construction of Axially Chiral 4-Arylquinoline via Acid-Promoted Dehydrative Cyclization/Oxidation of Diarylmethanols |
投稿时间:2019-07-17 修订日期:2019-07-30 |
DOI: |
中文关键词: 手性膦酸 轴手性 手性喹啉 |
英文关键词:chiral phosphoric acid axially chiral chiral quinoline |
基金项目:中国科学院百人计划,国家自然科学基金(21602231),江苏省自然科学基金(BK20160396) |
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中文摘要: |
我们发展了酸催化的二芳基甲醇的脱水环化氧化芳构化的方法,直接高产率(高达81%)的合成轴手性的4-芳基喹啉.而且,Lewis酸Zn(OTf)2和手性膦酸都能催化这个反应,初步的不对称研究可以用er 71:29得到产物. |
英文摘要: |
Acid-promoted dehydrative cyclization/oxidation aromatization sequences from diarylmethanols was developed, providing a new family of axially chiral 4-arylquinolines in high yields (up to 81%). Importantly, both Lewis acid Zn(OTf)2 and organic chiral phosphoric acid (CPA) are able to catalyzed this transformation and the asymmetric version was also primary investigated (up to 71:29 er). |
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