| 穆宏文,金言,王黎明,郑明善,金瑛.有机催化不对称Michael/环化串联反应的研究进展[J].分子催化,2022,36(6):584-602 |
| 有机催化不对称Michael/环化串联反应的研究进展 |
| Research Progress of Organocatalytic Asymmetric Michael/Cyclization Tandem Reaction |
| 投稿时间：2022-07-10 修订日期：2022-08-16 |
| DOI：10.16084/j.issn1001-3555.2022.06.007 |
| 中文关键词: Michael/环化串联反应 不对称催化 有机小分子催化剂 |
| 英文关键词:Michael/cyclization tandem reaction asymmetric catalysis organocatalysts |
| 基金项目:国家自然科学基金项目（NNSFC，GrantNos.81660646）；吉林省科技厅自然科学基金项目（YDZJ202201ZYTS552）资助 |
|
| 摘要点击次数: 412 |
| 全文下载次数: 1182 |
| 中文摘要: |
| 串联反应能够减少反应步骤、简化操作、降低成本、实现高效率转化，符合原子经济性和绿色化学理念.特别是有机催化的不对称串联环化反应以一锅法连续催化多个化学反应，为高效合成多手性中心环状结构提供了新方法.不对称Michael/环化串联反应是构建光学活性状化合物的常用方法之一，近些年，各种有机小分子催化剂应用于不对称Michael/环化串联反应的报道不断增加，并且取得了重大进展.我们根据不同的催化剂类型综述了近5年来关于不对称Michael/环化串联反应的研究进展，并对有机催化不对称Michael/环化串联反应的发展趋势进行了展望. |
| 英文摘要: |
| Reduction of reaction steps, simplified operations, cutting costs, and high-efficiency transformations can be achieved through Tandem reactions, which are in line with the concept of atom economy and green chemistry. In particular, the organocatalytic asymmetric tandem cyclization can accomplish domino chemical reactions in a one-pot manner, which provides a novel method for the efficient synthesis cyclic compounds with multiple stereocenters. The asymmetric Michael/cyclization Tandem reaction is one of the common methods to construct optically active cyclic structure. In recent years, reports on the application of various organocatalysts to asymmetric Michael/cyclization tandem reactions have been increasing, and much progress has been made in this fields. We reviewed the research progress on the asymmetric Michael/cyclization tandem reaction in the nearly five years according to different catalyst types, and the development trend of asymmetric Michael/cyclization tandem reaction in organocatalysis is prospected. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
