| 徐鹏程,刘玉玉,钱波,胡斌.钯催化的烯烃与三嗪烷氢胺羰基化反应研究[J].分子催化,2023,37(3):225-233 |
| 钯催化的烯烃与三嗪烷氢胺羰基化反应研究 |
| Palladium-catalyzed Hydroaminocarbonylation of Alkene with Triazine |
| 投稿时间：2023-02-10 修订日期：2023-03-16 |
| DOI：10.16084/j.issn1001-3555.2023.03.002 |
| 中文关键词: 钯催化 烯烃 1,3,5-三嗪烷 氢胺羰基化 烷基支链酰胺 |
| 英文关键词:palladium catalysis alkene 1,3,5-triazine hydroaminocarbonylation alkyl branched amide |
| 基金项目:中国科学院“西部之光”人才培养引进计划 |
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| 中文摘要: |
| 酰胺类化合物广泛应用于医药、 农药、 材料、 合成化学等领域, 因此, 新型且高效合成酰胺的方法一直具有很高的关注度. 我们首次使用环状脂肪三级胺类化合物—1,3,5-三嗪烷作胺源, 成功解决了钯催化的烯烃氢胺羰基化反应领域中脂肪胺对钯催化剂的毒化问题, 合成了多种烷基支链酰胺化合物, 并提出了可能的反应机理. |
| 英文摘要: |
| Amide compounds are widely used in medicine, pesticides, materials, synthetic chemistry and other fields. Therefore, the new and efficient synthesis methods of amides haveattracted high attention of chemists. In this approach, cyclic aliphatic tertiary amine 1,3,5-triazine was first applied as the amine source in the hydroaminocarbonylation transformation of alkene via palladium catalysis, affording virous alkyl branched amide compounds. Additionally, the problem of palladium catalyst poisoning by the aliphatic amine was successfully addressed by this protocol. Furthermore, a possible reaction mechanism is proposed. |
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